Is pig11 expression a prognostic biomarker for gastric cancer?
Therefore, PIG11 expression may be associated with the malignancy of GC and may serve as a potential diagnostic and prognostic biomarker for GC. Gastric cancer (GC) is a common malignant tumor type of the digestive tract with high morbidity and mortality ( ). The 5-year survival probability of a patient with GC is <20% ( ).
What happens when pig11 is overexpressed?
As reported in another study, overexpression of PIG11 may change metabolic pathways and metabolites of redox processes, such as the changes of NADPH oxidase in the membrane ( 45 ). Apoptosis of epithelial cells depends on the attachment of integrin-mediated extracellular matrix (ECM) ( 46 ).
Are pig11 and TNM stage independent prognostic factors for colon cancer?
Further multivariate analysis indicated that high PIG11 expression (HR=2.926; P<0.001) and TNM stage (HR=1.578; P=0.021) were independent prognostic factors for GC ( Table III ).
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